Christian P Speer Selected Research

CHF5633

12/2022	A first-in-human clinical study of a new SP-B and SP-C enriched synthetic surfactant (CHF5633) in preterm babies with respiratory distress syndrome: two-year outcomes.
11/2017	A first-in-human clinical study of a new SP-B and SP-C enriched synthetic surfactant (CHF5633) in preterm babies with respiratory distress syndrome.
1/2017	Anti-inflammatory effects of the new generation synthetic surfactant CHF5633 on Ureaplasma-induced cytokine responses in human monocytes.
10/2016	The new generation synthetic reconstituted surfactant CHF5633 suppresses LPS-induced cytokine responses in human neonatal monocytes.
1/2016	Effects of the New Generation Synthetic Reconstituted Surfactant CHF5633 on Pro- and Anti-Inflammatory Cytokine Expression in Native and LPS-Stimulated Adult CD14+ Monocytes.

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Christian P Speer Research Topics

Disease

19	Inflammation (Inflammations) 01/2019 - 10/2006
14	Chorioamnionitis 03/2011 - 02/2005
12	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 12/2022 - 01/2004
10	Bronchopulmonary Dysplasia 01/2021 - 06/2007
10	Lung Injury 01/2019 - 01/2004
9	Infections 08/2020 - 02/2003
7	Airway Remodeling 01/2018 - 01/2007
6	Newborn Respiratory Distress Syndrome 01/2021 - 01/2011
6	Lung Diseases (Lung Disease) 01/2021 - 02/2004
4	Premature Birth (Birth, Premature) 01/2019 - 01/2008
3	Neonatal Sepsis 08/2020 - 12/2013
3	Pneumonia (Pneumonitis) 01/2017 - 01/2004
3	Vascular Remodeling 01/2012 - 09/2005
3	Hypoxia (Hypoxemia) 09/2011 - 01/2004
2	Neuroinflammatory Diseases 03/2022 - 05/2018
2	Body Weight (Weight, Body) 08/2020 - 05/2010
2	Rupture 08/2020 - 12/2005
2	Hereditary Spherocytosis 11/2019 - 12/2015
2	Birth Weight (Birth Weights) 01/2019 - 01/2004
2	Perinatal Death 10/2013 - 06/2013
2	Pneumothorax 10/2013 - 06/2013
2	Fibrosis (Cirrhosis) 01/2007 - 10/2006
2	Meconium Aspiration Syndrome 01/2004 - 01/2003
1	Mucopolysaccharidoses 03/2022
1	Mucopolysaccharidosis III (Sanfilippo Syndrome) 03/2022
1	Hypertension (High Blood Pressure) 01/2021
1	Pre-Eclampsia (Preeclampsia) 08/2020
1	COVID-19 01/2020
1	Reticulocytosis 11/2019
1	Pyruvate Kinase Deficiency of Red Cells 11/2019
1	Hereditary Elliptocytosis 11/2019
1	Premature Obstetric Labor (Premature Labor) 01/2019
1	Brain Injuries (Brain Injury) 05/2018
1	Coinfection 01/2018
1	Ureaplasma Infections (Ureaplasma Infection) 01/2018
1	Respiratory Syncytial Virus Infections 01/2018
1	Infantile Spasms (West Syndrome) 03/2015
1	Long Term Adverse Effects 01/2015
1	Sepsis (Septicemia) 03/2014

Drug/Important Bio-Agent (IBA)

18	Surface-Active Agents (Surfactants)IBA 12/2022 - 01/2004
8	Oxygen (Dioxygen)IBA 01/2021 - 01/2004
7	Caffeine (No Doz)FDA LinkGeneric 01/2019 - 01/2012
7	GlucocorticoidsIBA 01/2019 - 01/2008
7	Connective Tissue Growth FactorIBA 01/2018 - 01/2007
6	CytokinesIBA 01/2017 - 02/2003
5	CHF5633IBA 12/2022 - 01/2016
5	SteroidsIBA 01/2019 - 10/2010
3	LipopolysaccharidesIBA 05/2018 - 02/2009
3	Transforming Growth Factor beta (TGF-beta)IBA 01/2018 - 02/2004
3	Proteins (Proteins, Gene)FDA Link 01/2014 - 04/2009
3	Transforming Growth Factors (Transforming Growth Factor)IBA 03/2013 - 02/2004
3	Interleukin-6 (Interleukin 6)IBA 09/2011 - 02/2005
3	Interleukin-8 (Interleukin 8)IBA 03/2011 - 01/2004
3	LipidsIBA 10/2006 - 01/2003
2	CaspasesIBA 03/2022 - 01/2019
2	Progesterone FDA LinkGeneric 01/2019 - 01/2018
2	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA 01/2018 - 02/2005
2	transgelinIBA 01/2018 - 01/2014
2	Messenger RNA (mRNA)IBA 01/2018 - 01/2008
2	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 01/2018 - 02/2005
2	Interleukin-10 (Interleukin 10)IBA 01/2017 - 03/2011
2	RolipramIBA 01/2014 - 01/2012
2	Toll-Like Receptors (Toll-Like Receptor)IBA 12/2013 - 09/2011
2	Transforming Growth Factor beta1 (TGF beta 1)IBA 01/2007 - 10/2006
2	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2006 - 01/2004
2	Peptide Hydrolases (Proteases)FDA Link 10/2006 - 01/2004
2	NF-kappa B (NF-kB)IBA 09/2005 - 01/2004
1	EnzymesIBA 03/2022
1	Heparitin Sulfate (Heparan Sulfate)IBA 03/2022
1	heparan sulfate sulfataseIBA 03/2022
1	GlycosaminoglycansIBA 03/2022
1	Biomarkers (Surrogate Marker)IBA 08/2020
1	S100 Proteins (S 100 Protein)IBA 08/2020
1	S100A12 ProteinIBA 08/2020
1	Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA 11/2019
1	Membrane Proteins (Integral Membrane Proteins)IBA 11/2019
1	Pyruvate KinaseIBA 11/2019
1	cytomegalovirus-specific hyperimmune globulinIBA 01/2019
1	Chemokine ReceptorsIBA 05/2018
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2018
1	Smad Proteins (Mothers Against Decapentaplegic Homolog)IBA 01/2018
1	Plasminogen Activators (Plasminogen Activator)IBA 01/2018
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2018
1	Ferritins (Ferritin)IBA 06/2017
1	PerforinIBA 06/2017
1	Interleukin-2 Receptors (IL 2 Receptor)IBA 06/2017
1	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 01/2017
1	Interleukin-12 Subunit p40IBA 01/2017
1	Glycerol (Glycerine)FDA LinkGeneric 12/2015
1	VitaminsIBA 03/2015
1	Betamethasone (Celestone)FDA Link 01/2015
1	Dexamethasone (Maxidex)FDA LinkGeneric 01/2015
1	Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)IBA 05/2012
1	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 01/2012

Therapy/Procedure

11	Artificial Respiration (Mechanical Ventilation) 01/2021 - 01/2004
7	Therapeutics 01/2021 - 06/2007
3	Resuscitation 01/2020 - 01/2004
1	Noninvasive Ventilation 01/2021
1	Continuous Positive Airway Pressure 01/2019
1	Neonatal Intensive Care 07/2014